:: Przegląd tematu - Ocular injection of cyclosporine A, ε- Caprolacto

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Ocular injection of cyclosporine A, ε-Caprolactone-D, L-lactide copolymer microspheres embedded Stability Study

Significant change. Tip CsA microspheres preparation in the light conditions better physical and chemical stability. 3.4 at room temperature observations to stay kind to stay like that CsA microspheres observations did not find visible mold preparation, and good liquidity in the shaking time, there is no agglomeration. Assay results show that the chemical stability. 3.5 CsA at different temperatures in the degradation of microspheres in each different temperature, Xilin bottle lOmgC_, sA CsA microspheres the amount of change at different times of 0,1 and 2 respectively deal with reaction equation to obtain the order reaction rate constant. The level of the rate constant for a reaction to take the natural logarithm, lnk temperature (absolute temperature) of the reciprocal (1 / T) for linear regression, the results show that the lnk and 1 / T linear relationship between the poor. Both by degradation of 0,1 and 2 deal,tory burch outlet, lnk and the l / r is not a linear relationship between the good, indicating that CsA PCLA microspheres degradation does not meet the AiThe, nius exponentially. 4 Discussion of the PCLA CsA microspheres are solid dosage forms, drug decomposition is slow,timberland shoes, the degradation kinetics of this research is very difficult. CsA in this study the content changes in a variety of conditions, not large, the reasons for this may be due to CsA was evenly distributed in the polymer composition of the microspheres, although in the 55 ~ C above the microspheres occurred the melting phenomenon, but because PCLA lipophilic, so that lipophilic drugs remains evenly dispersed in the polymer matrix, while the experiment is under investigation in a sealed, even if there is water there, because the hydrophobic polymer and drug, dispersed in the polymer matrix of the drug would not have more contact with the water opportunities, so the opportunity to be less water to break down. CsA in the case of light illumination remained stable, and CsA may be evenly dispersed in the microspheres, and be protected, so that by the light CsA microspheres were still stable. The interaction between CsA and PCLA, making comparisons PCLA raw materials, CsA and CsA the PCLA IR spectra of microspheres, the analysis shows that the characteristic peaks of CsA still exists,belstaff milano, there is no mutual reaction. As the PCJA CsA microspheres will occur at 55 ℃ melt, even though CsA remained stable, but pose a problem of disinfection agents,ghd piastre, that can not be sterilized by heat sterilization methods. In conclusion,belstaff outlet, this study confirmed that the PCLA CsA microspheres at room temperature, and light case is relatively stable. In the case of high temperature melting occurs, undermining the existence of microspheres, therefore, should avoid high temperature storage.