 Wysłany: Wto 23:22, 01 Mar 2011 Temat postu: Degenerative diseases of the central nervous syste |
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| Degenerative diseases of the central nervous system development and research overview
urtDrugTargetsCNSNeurolDisord ,2004,3:137-152. 【3] MuirJL. Acetylcholine, aging, andAlzheimer'sdisease 【J]. PharmacolBiochemBehav ,1997,56:687-696. [4] Zhongchong Bo,ghd outlet, Xu Xianghua, WANG Xiao. Alzheimers Disease Research cholinergic theory [J]. ChinesePharmacolog; calBulletin ,2003,19:727-731. [5] Xu Bao, Wu Xun. Amyloid precursor protein in Alzheimer's disease in molecular biology and clinical research progress [J]. Chinese Academy of Medical Sciences of ,2003,26:201-209. [6jRachakondaV, PanTH, LEWD. Biomarkersofneurodegener-ativedisorders: howgoodarethey? [J]. CellRes ,2004,14:347-358. [7jRingheimGE, ConantK. NeurodegenerativediseaseandthePrP. PrPre. Can cause neurodegeneration of the cerebral cortex and other normal PrP conformational changes. PrP aggregation can lead to loss of neuronal function,ugg schuhe, vacuolar degeneration and death. The abnormal P protein can be transmitted between patients and controls, such as through the pituitary extracts, corneal transplantation, dura mater and nerve graft surgery in the course of the electrode with the pollution. Closely related with the incidence of abnormal PrP gene, such as codon 178, encoding aspartate into asparagine, the same allele codon 129,tory burch reva, methionine is present if the encoding type hypothalamus CJD; such as coding is valine, it is distributed CJD-like symptoms; and when the encoded tyrosine codon into a stop codon 145 neutrons, the patient up to 20 years duration, and showed AD-like dementia; such as 180 codon encoding isoleucine replaced by valine, codon 200 encoding glutamic acid is lysine replacement, codon 232 encoding methionine replaced by arginine, is manifested in familial CJD :139-149. 【9] GardianG, VecseiL.Huntington 'sdisease: pathomeehanismandtherapeuticperspectives [J]. JNeuralTransm, 2004, l11 :1485-1494. [10] CollinsB, ConstantJ, KabaS, etod.Dementiawithlewybodies: impHcationsforclinicaltrials [J]. ClinNeuropharma . col ,2004,27:281-292. [11] uchihamT, IkedaK, TsuchiyaK.PickbodydiseaseandPicksyndrome [J]. Neuropathol ,mbt shoes italia,2003,23:318-326. [12] MallueeiG, CollingeJ.UpdateonCreutzfeldt.Jakobdisease [JJ.CurtOpinNeurol,ugg stiefel, 2004,17:641-647. |
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