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SSRI use during pregnancy and fetal abnormalities

Agent can increase nitric oxide (NO) levels, NO can increase cGMP levels, so that cavernous smooth muscle relaxation,uggs kopen, increasing blood supply. Recent studies indicate that these inhibitors can enhance the NO mediated these effects. Although NO in the pathophysiology of epilepsy, the role is also highly controversial, but NO and cGMP signaling pathway on E epileptic seizure ADVER summer threshold of adverse effects may increase susceptibility to epilepsy. Moreover, sildenafil and exogenous or endogenous release of NO interaction,ghd outlet, has been shown to change the seizure threshold effect. However, a PDE 5, the exact change in seizure susceptibility is not clear. In this paper, the article submitted by the author, the other a 78-year-old patient at the 2nd oral vardenafil 10mg of epilepsy after partial seizures. This further confirms the phosphodiesterase inhibitor in taking after the possibility of epileptic seizures. [Source BMJ2006; 333:785 (14October), d0i: l0.1l36/md. 38953.758565.791 use of SSRI during pregnancy and fetal abnormalities, a new study reports that in early pregnancy for a period of 5 to take selective serotonin reuptake inhibitor (SSRI) were born of women fetal malformations may increase. But researchers said the increase is unclear because of the danger caused by the drug itself or with women suffering from diseases other factors. The study, published online in the Oct. 4 issue of Popular Science magazine EPiDE-on to win. The study showed that in pregnancy the first 2 or 3 months of taking the SSRI can make the risk of fetal malformations at birth to 2 times. While taking other types of antidepressants or SSRI in late pregnancy will not make that risk taking increases. From Aarhus University Hospital of Denmark,moncler uomo, said, Current SSRI teratogenicity in the human aspects of the information is still limited because the study was small. Women in the study of 151,831 cases, there are 1051 cases (0.7%) in early pregnancy (defined as from the conception of the first 30 days to 3 months of pregnancy only) using the SSRI. Of these, 453 patients (0.3%) in pregnancy 2 or 3 months prescription of SSRI. The results showed that 150,780 cases of women not given SSRI in 5112 cases (3.4%) of fetal birth defects, and 1,051 cases at any time during early pregnancy of women taking the SSRI, 51 patients had abnormal fetal malformations (4.9 %) (adjusted relative risk 1.34,belstaff milano,95% CI1-1.79). In pregnancy,ghd piastre, the first 2 or 3 months, 453 cases of women taking the SSRI, the rate of occurrence of birth defects was 6.8% (adjusted relative risk 1.84,95% CI1.25-2.71). SSRI use in early pregnancy birth defects occurred mainly in the cardiovascular system (29%), muscle and skeletal systems (31%) or digestive (14%) deformities. The authors say, there is no evidence that the occurrence of specific malformations, indicating that may be 5 to the role of serotonin caused by their own. / bmd.333.7573.824-d) (compiled YANG Chang Shan) China Prescription Drug 2OO6.11. No. 56l71
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