scarpe mbt Pyrogen injection and control method ou -

06nike7394ud

Pyrogen injection and control method outlined

Company), RCZ 8B-type drug dissolution of a meter (Tianjin University Precision Instrument Factory). Potassium chloride (hard Pharmaceutical Co., Ltd., Jiangsu Province, lot number 20070311), hydroxypropyl methyl cellulose (HPMC, Huzhou Looking Pharmaceutical Co., Ltd., lot number 200701042), lactose (Biological Engineering Co., Ltd. Changzhou Lansen , lot number 601030), microcrystalline cellulose (Qufu Tianli Pharmaceutical Excipients Co., Ltd., lot number 20061210), You Teqi NE30D (EudragitNE30D, Germany Roma Company, lot number E060901021), polyethylene glycol 4000 (PEG4000, Liaoyang Huaxing medicinal plant materials,[link widoczny dla zalogowanych], lot number 7030), fine talcum powder (talc products Guilin afterlife limited liability company, lot number 20070111), polyvinylpyrrolidone (PVP, Shanghai Fine Chemical Co., Ltd. Cheng thick,[link widoczny dla zalogowanych], grant No. 20061215), potassium chromate (Shanghai Reagent Plant, AR), silver nitrate (Beijing Chemical Reagents Company, AR). 2 Methods and Results 2.1 Preparation of the potassium chloride potassium chloride tablets crushed core, over 100 mesh sieve, reserve; prescription will be crushed by potassium chloride, lactose and microcrystalline cellulose in turn set the mixer trough, amount of HPMC made an alternative solution as adhesive, stirring the system of soft material, the wet system than 20 mesh particles, dried whole, the total mixing core particles derived potassium chloride tablets, tablet use. 2.2 The coating process of the preparation of sustained-release coating solution: the die by the quality of the polymer weighed 7% EudragitNE30D, add water and cause larvae L agent, stir, with high shear homogenization homogenization machine, 100 heads screen filter, that is, too. Coating process should continue stirring. Package release clothing layers: the core set of potassium chloride tablets coated pan, spray distance from the bed sheet 20am, piece bed temperature (35 ± 3) ℃, spray rate 0.1L/min, atomization pressure of 0.3MPa, coating pan speed 7r/min,[link widoczny dla zalogowanych], coating after heating, curing, that is, too. Coating process, the foreign agent than L larvae caused by the relevant process parameters are fixed, including the polymer dosage, bed sheet spray distance, spray liquid flow rate, atomization pressure, curing temperature, curing time, the operator and every pot chip core content, were investigated on the basis of different types and amount of potassium chloride caused by larvae L agent on the release of sustained-release tablets. 23 samples taken for determination of release, according to release assay, dissolution test method using the device to 900mI distilled water as release medium, the speed is 50r/min, according to operation, were taken late in the 1,2,4,6,8 h 25mL solution filtration,[link widoczny dla zalogowanych], and stripping in time to add the cup distilled water with temperature, precise amount of filtrate added 20mL, add 4 drops of potassium chromate indicator solution, titration with silver nitrate solution (0.01mol / L) titrated to a solution were orange. Each 1mL solution of silver nitrate titration (0.01mol / L) potassium chloride equivalent to 0.7455mg. 2.4 porogen cumulative release percentage of test /% PEG4000: PEG4000 is commonly used porogen has good film forming properties. For the water-soluble drugs, the release of its quality of materials used amounted to 10% to 20% release rate can meet the requirements of l. This test will be designed to gather the amount of the respective amount of 5% + 10% of the amount of dosage 20% t/h02468 Figure 1 Effect of PEG4000 on the amount of release of potassium chloride complex quality 5%, 10%, 20% were coated 3 times. The results shown in Figure 1. Visible, 3 with ● 'll'm'Il, I'','. 1. ,'', ● m, I, ', m',''',',,,'' ● m, m'lI,,,, ll, Ii. ,,,,, L, 'm',,'',,,'', m'm',, m,'', 17 (5) :27-28. Chi. 1999.16 (4) :234-235. 【9】 Li Li, Li Jiankai, Duan Shuying, et al. Secondary sterilization failure infusion of thermal quality of the original [J]. [11] Xu Yinghong, Tang Shoulin. PH and the oxidant damage and heat inactivation of the original experimental observations [J]. Modern Applied Pharmacy, 2006,23 ( Super

:812-813. Liaoning drugs and IIC,, 1999.2 (4) :32-33. [10] into the country song, like the Shao people. Heating sugary infusion of heat inactivation of the original method [J】. DISINFECTION Miscellaneous
More articles related to topics：

mulberry bags sale Xiangfan catastrophe away _4722

[link widoczny dla zalogowanych]

mbt zapatos A world crisis under _3989

				fora.pl - załóż własne forum dyskusyjne za darmo Powered by phpBB © 2001, 2002 phpBB Group Avalanche style by What Is Real © 2004