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Śro 21:39, 02 Mar 2011 |
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Autor |
Wiadomość |
nrzxfquxq
95%
Dołączył: 13 Gru 2010
Posty: 557
Przeczytał: 0 tematów
Ostrzeżeń: 0/5 Skąd: England
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Temat postu: Patients with acute coronary syndrome detection an |
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Patients with acute coronary syndrome detection and significance of PAI-1
1.1 Clinical data and methods included in the study of the ACS [acute myocardial infarction (AMI),[link widoczny dla zalogowanych], unstable angina pectoris (UAP): and SAP are character sets of patients in WHO 1979 diagnostic criteria established coronary heart disease, some patients after confirmed by coronary angiography,[link widoczny dla zalogowanych], and no serious liver, kidney disorders and blood diseases. Healthy control group for the examination of normal healthy people. Characteristics of patients in each group the information in Table 1. Table 1 Data characteristics of patients in each group (z ±) Note: The iodine group were not significantly different with t are P> O. O5) 1.2 Research Methods blood immediately after admission in patients with AMI, the rest of the morning fasting venous blood of patients in order to dig sodium citrate anticoagulant,[link widoczny dla zalogowanych], centrifuged immediately separated the plasma, set a 20C refrigerator. By chromogenic substrate method PAl1 and tissue-type plasminogen activator (tPA) activity (kit from Shanghai Medical University,[link widoczny dla zalogowanych], Institute of Molecular Genetics) by Enzymatic determination of total cholesterol (TC), triglyceride (TG) , high density lipoprotein cholesterol (HDI A C). 1.3 Statistical analysis indicated that mean to xts; measurement data applications t test. Count data application testing. 2 Results AMI group and UAP group PAI1 activity were significantly higher than sAP group and the healthy control group (P 0 .0. AMI group and UAP group slightly lower than the level of tPA activity in SAP group and the healthy control group, but each group no significant difference between Chuang (P> 0.05). Table 2, Table 2 in each group heard PAI - 1 and tPA activity levels between (j ±) to: Health trench control group. P> 005. P 005), prompted ACS patients undergoing coronary artery thrombosis and fibrinolytic activity decreased mainly related to further explore the anti-platelet ,[link widoczny dla zalogowanych], anti-coagulation and fibrinolysis in patients with ACS plasma treatment on the impact of PAl-l, may have important clinical significance. 4
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