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Rabbit model of Acanthamoeba keratitis and ocular manifestation of the organizational characteristics

lulcers. Cornea. l996.15: 566.7 'Vail Ⅺ F, AlizadehH, HeYu, eta1. eroleofcontactlelrlSe8, traun ~, andlungerhanscellsinaChinl ~ enal ~ termodelofacanthamoebakeratitis. In, ~ estOohth, amolVisSci, l993. 343: l937.8HeYu, McCuUeyJP, AlizadehH, eta1. Apigrindelofacanthamoe ~ keratitis: hrl head nissi0Ilviacontaminatedcontactlenses. InvestOphthalmolVisSci. 1992. 33: l26.9LarkinDFP. EastyDL. Expefinmltalacanthamoe ~ keratitis: lPreliminary ~ 1ndin ~. BrJOphth ~ ol, l990, 74:551.10 NiedenkomJY, gbelak ~ JE, McCuUeyJP, eta1. Susceptilityofcorneasfromvariousanimalspeciestoinvitrobi. aingandinvasioabyacanthamoe ~ castellani. InvestOphth, amolVisSci. 1992,33:104. (Received: l998-0l a 2l Revised: l998-o7-31), a congenital corneal cataract Department, Zhou Liqun Wu Shixin,, ', congenital cataract is a common congenital eye disease, congenital congenital corneal merger Clinical Ophthalmology cataract is rare. Seeing patients in our department, a department, are as follows. Proband: Xu X, female, 13 years old. 2 years of age found that binocular vision is poor, 4 years old to make artificial pupil in patients outside the hospital. Parents of non-kin marriage,[link widoczny dla zalogowanych], disease-free history of the mother during pregnancy. General physical examination was normal. Eye examination: visual acuity of 0.04, 0.05 left eye vision, do not accept the lenses. Eyes rotate tremor. Double corneal longitudinal diameter, transverse diameter are 8.5mm, transparent, normal anterior chamber, iris visible nasal defect surgery, lens thin, mixed up, eyes peep unclear. Normal positioning of light, red,[link widoczny dla zalogowanych], green felt suspicious. Refers to the measured intraocular pressure is normal. Example 2: Xu x, a cousin of the proband, male, 16 years old, found that poor eyesight since childhood. Parents of non-kin marriage, his mother Zengyin cold medication during pregnancy, specifically unknown. General physical examination was normal. Eye examination: visual acuity of 0.04, 0.03 left eye vision, do not accept the mirror of Figure 1 Pedigree Unit: 200051 Shanghai Changning District Central Hospital of film. Eyes rotate tremor. Double corneal longitudinal diameter,[link widoczny dla zalogowanych], transverse diameter are 8mm, transparent, normal anterior chamber, membranous cataract, part of the absorption, eyes peep unclear. Positioning and red light, green felt normal. Refers to the measured intraocular pressure is normal. See Pedigree pedigree investigation. Discussion: The disease is characterized by the above-mentioned cases: small eyes, cornea, lens membrane opacity, rotate the eye tremor, vision is poor. Pedigree,[link widoczny dla zalogowanych], 3 of 5 people on behalf of sick members, male 2, female 3. Survey results show: Family illness was continuous intergenerational transmission; patients must have a parent in the human disease, and are heterozygous, fellow patients, about 1 / 2 may be sick; disease-free parents, the children generally do not disease; disease transmission and unrelated to sex, that men and women can be genetic, and equality of opportunity. The purpose of this pedigree in full compliance with Mendelian inheritance in the autosomal dominant inheritance completely. According to statistics, the incidence of congenital cataract is about 0.4%, students 30% of blind children due to cataract. Most genetic and chromosomal congenital cataract, which may be dominant or recessive inheritance. The former directly by the parent of genetic and disease, his parents were suffering from at least one cataract. Between the two generations can be different types of congenital cataracts. In addition, embryonic development, due to local or systemic disorders can cause lens opacity. Nutrition during pregnancy if the mother or metabolic disorders pm (vitamin A deficiency, parathyroid dysfunction, calcium metabolism, etc.), and maternal infection during early pregnancy (rubella, measles, chicken pox, mumps, etc.), syphilis, can cause fetal congenital cataracts. (Received: l997-O9 a l9) I Ⅱ Ⅲ
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