Myelodysplastic syndrome phenotype of _4426 -

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Myelodysplastic syndrome phenotype of the immune

Gradually reduced, accompanied by T lymphocyte antigen expression in a gradually disappear, whether RAEB ~ AEB. t stage, or in patients with MDS switch AL4 AML. M: group show significant increase in early myeloid antigen, showed similar antigen expression, confirmed that MDS is mainly myeloid dysplastic a group of diseases. Gradually increased in the CD ∞ at the same time, the early stem cell differentiation antigen CDHAL a leukemia lymphoma in April 2004 Volume 13 No. 2 DR, CD is also shown in RAEB ~ AEB-t was higher than RA. CD is a characteristic of hematopoietic stem cells, signs, most scholars believe that with acute myeloid leukemia type related, have also been reported in recent years is directly related with the MDS. In 1990, Guyotat other I3J immunization in 35 cases of MDS classification determination, CD only expressed in the RAEB ~ AEB-t. Chen Guibin other MDS subtypes cD maker reported cell count, there were significant differences. With the progress of MDS, namely RA to RAEB ~ AEB-t conversion, CD Chu cells was increased gradually, and easy conversion to leukemia. The results show that this group, CD, and other early antigen expression increased in poor prognosis. Its high expression in MDS MDS revealed the malignant degree. About MDS with MF, the test results are also evident for the HLA-DR, CD Yu-positive rate increased, and the cD cells are more pure RA or RAEB ~ AEB-t was defined as high, indicating that the MDS with MF compared with MDS who simply worse prognosis, more deserves clinical attention. 6 cases of RA in this group of patients at diagnosis to reduce the three lines in 3 cases, l cases showed reduction of two-line, 2 1 Department to reduce the performance. Bone marrow hematopoietic progenitor cells 0-2 ‰ obvious pathological, clinical have considered chronic aplastic anemia, ITP, and megaloblastic anemia, and ultimately bone marrow biopsy, 2 patients with fibrous tissue proliferation, combined with immunophenotyping, 6 patients had 2 or more than 2 myeloid antigen increased, in part also by further clinical impairment, megaloblastic anemia and I, I'P treatment were ineffective. All final diagnosis of MDS. Thus, abnormal immune phenotype is objective, useful signs, the diagnosis of MDS can be used as reference. One CDl5, CDCDHLA-DR, CD stand a greater change in immune markers, while T. Lymphoid gradually decrease as the disease advances CDCDHAL-DR expression of a certain prognostic significance. Tefferi such a chain with x restriction fragment length polymorphism of the 7 cases of MDS, clonal origin, the results showed that the expression of immune markers for the MDS series of abnormal, it may have originated in the abnormal proliferation of pluripotent stem cell cloning Court. . 【
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