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『 further confirmed the previously reported 2]. 43 cases ( 40.6%) mutations occur in between drug l2 ~ l8 months . That the level of serum viral load , the more prone to YMDD mutation ,[link widoczny dla zalogowanych], and generation time earlier. The basis of clinical experience also suggests that a large number of high level viral resistance and easy . This has become a consensus. But the foundation } Ding 3, plants I] INA What Level is easy to produce drug resistance ? current inconclusive on this issue . We compared drug resistance and treatment before the I-IBVDNA load , which shows less than 6.3log HBVDNA lamivudine treatment were . Treatment resistance did not occur 32 months ; HBVDNA than 8.3log thereof l2 ~ l8 months,[link widoczny dla zalogowanych], resistance occurred ; and viral load between the average treatment period of 32 months was 25.9% of drug resistance . The results for the early prediction of lamivudine resistance provided valuable quantitative indicators . Based on the results of this study , clinical practice,[link widoczny dla zalogowanych], on the basis of virus levels in patients with chronic hepatitis B is greater than 8log . High risk of lamivudine resistance can be called , it is recommended to avoid using lamivudine as the first oral antiviral drugs, such as low resistance option entecavir or adefovir dipivoxil . The basis of virus levels below the 6log who is 32 months of lamivudine therapy is relatively safe. The results of this large sample study to be further confirmed. For high risk patients resistant to lamivudine lamivudine therapy. After 12 months , should be closely monitored at least every 3 months YMDD mutation,[link widoczny dla zalogowanych], found to have variant to take countermeasures in time after 『 3].
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