Development and production of acetic acid trimethy -

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Development and production of acetic acid trimethyl

5, No. 3 chemical raw materials and intermediate development aims South j j 11 a method of producing oxo. Preparation of trimethyl-Oxo acid has two reaction Reppe and Koch method, Reppe Synthesis of carboxylic acids in the transition metal carbonyl compounds, the presence of catalyst, olefin, CO and water are synthesized acid isomers and mixtures of isomers. The most important complex catalyst is nickel,[link widoczny dla zalogowanych], cobalt, rhodium, platinum, palladium and iron carbonyl compounds. If the metal and select the appropriate ligand, the catalyst can be very mild conditions for the carbonylation of olefins reaction product is trimethyl acetic acid and isovaleric acid. Koch reaction temperature was between a 20qC ~ 80 ℃, the reaction pressure in the IOMPa less raw materials to determine the reaction of carbonyl olefin acid isomers on the type and distribution,[link widoczny dla zalogowanych], usually straight chain hydrocarbons with branched chain olefins than the hard, branched-chain olefins generated high purity and high yield of tertiary carbon acid. Currently, Koch reaction has established a pilot production plant. Isobutanol or tert-butyl alcohol and formic acid synthesis in the presence of sulfuric acid trimethyl. Koch acid synthesis reaction of trimethyl derivative method is 95% concentration of sulfuric acid, isobutanol or tert-butyl alcohol with concentrated formic acid reaction, the reaction process and Koch were similar, with the synthesis of trimethyl acetic acid tert-butyl alcohol can be more response to low temperature, generally 20 ~ (7-25 ~ E under the isobutyric acid and formic acid added to sulfuric acid droplets, the reaction time of 10 hours, the yield of 65% or more. isobutyl alcohol formic acid method advantage is that atmospheric reactions, alcohol easy storage and transport of raw materials, but the acid is expensive, and more than 99% purity. Methyl tert-butyl ketone haloform reaction, methyl ketone or secondary alcohol and sodium bromide and sub- sodium hydroxide aqueous solution of sodium bromide in the reaction to take acid and bromoform at 60 \chloride with 2-2-methyl propane reacted with magnesium Grignard reagent and then with CO: reaction, and then to 25% of the sulfuric acid hydrolysis of trimethyl acetic acid, the yield was 63%. take the gray {Products \Ling band band band titi acetone as the raw material obtained by pinacolone trimethyl acetic acid, in the presence of mercuric chloride, acetone and pinacol reaction of magnesium Magnesium, hydrolysis reaction of pinacol, rearrangement under acidic conditions are pinacolone,[link widoczny dla zalogowanych], and then oxidation of bromine and sodium hydroxide, trimethyl acetic acid obtained by acidification of the law more complicated, long process. 3, the domestic development of the three methyl acetate and market trends in China in the 20th century 70 trimethyl acetic acid has been studied, but as yet no formal industrial production plant. In 1973, the second chemical plant in Fuzhou, sulfuric acid with different acid production of trimethyl acetic acid, 3-liter reactor in the synthesis, after synthesis , separation, purification and drying processes, the yield of trimethyl acetic acid 70%, merely small-scale pilot,[link widoczny dla zalogowanych], and later production. At present, the domestic research and development of isobutyric acid or sulfuric acid tert-butyl alcohol formic acid synthesis of trimethyl are no major technological breakthroughs. At present, the domestic use of imported trimethyl acetic acid production PV initiator; about three dozen pharmaceutical use of methyl acetate to produce ampicillin, cefazolin antibiotic drugs; to three methyl acetate hexanol and tert-PVC was synthesized in effect peroxide initiator acid tert-amyl had Kitt (HPP) has been included in the production plans. In recent years, China's imports of trimethyl acetic acid maintained at 2000 ~ 3000t / a level on the production of fine chemicals in China with the rapid development of trimethyl acetic acid trimethyl market demand will reach 400Or / a or so. With the production of fine chemicals in China's development, construction trimethyl acetic acid production plant has become priority, the scale of production to 5000t / a suitable production Cf-C.. of carboxylic acid, arrange production according to market demand planning trimethyl acetic acid, azelaic acid and different needs of other fine chemical acids, more economical and reasonable. now is different azelaic acid and other acids have a greater number of imports each year, construction of domestic and international market conditions may be arranged after the export. trimethyl acetic acid 【English name】 Pivalicacid; 2,2 a Dimethylpr0pan0icacid; Trimethylaceticacid】【CAS Registry Number 75-98-- 9 【Chemical name】【formula 2,2 or two methyl propionic acid, molecular weight】【Alias】 CsHto02102.13 special acid, tert-acid】【physical and chemical properties of colorless crystals. melting point 35-3 ℃, boiling point 163 .7 ℃. relative density (d) 0.905, refractive index (n) l ・ 393. soluble in water, soluble in alcohol and ether.

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