Clinical organ transplant donor matching _4520 -

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Clinical organ transplant donor matching

Produced cytotoxic antibodies,[link widoczny dla zalogowanych], once implanted in the donor organ, these stored graft antibodies and antigens play a role. At the same time activate the complement, damage to vascular endothelial cells. Platelet and neutrophil aggregation, fibrin deposition,[link widoczny dla zalogowanych], causing thrombosis intravascular coagulation profit,[link widoczny dla zalogowanych], resulting in graft necrosis, loss of function,[link widoczny dla zalogowanych], and sometimes even hyperacute rejection by those who endanger lives. Once hyperacute rejection, no immunosuppressive drug treatment is ineffective. In order to avoid hyperacute rejection. Transplantation recipients before the body needs to be carefully checked whether the stored anti-donor antibodies. For highly sensitized recipients. Feasible in the transplant plasma exchange before surgery to help remove the stored antibodies that cross-lymphocytotoxicity test 30 minutes,[link widoczny dla zalogowanych], cold ischemia time should not be> 24 hours. Current shortage of donor I still hinder the development of the main obstacles to clinical transplantation. Reasonable application of the body except for those further, it should also strongly encourage the promotion of living donors. For minimizing the gap between China and developed countries. (Il Contributions to: 199 607】 0)

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