Advances in the diagnosis of venous embolism _3 -

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Advances in the diagnosis of venous embolism

rdetectionofacutepulmonaryembolism: allin-depthreview. Chest ,2003,[link widoczny dla zalogowanych],124:2324-2328 .23 SinharayR. Acost-effectiveobjectiveapproachtoaiddiagnosisofdeep-veinthrombosis (DVr) andpulmonaryembolism (PE)> Q. JMed ,2003.96:687-688 .24 TorbickiA, VanBeekEJ, Chad ~ nnierB, eta1. Guidelinesondiagnosisandmanagementofacutepulmonaryembolism. EurHeartJ ,2000,21:1301-1336 .25 WellsPS, GinsbergJS, AndersonDR, eta1. Useofaclinicalmodelforsafemanagementofpatientswithsuspectedpulmonaryembolism. AnnInternMed ,1998,129:997-10o5. (Received 13 :2006-06-12) Abstract In recent years, with the disease increases, the need for functional arterial replacement is also growing, small-caliber arteries such as the below-knee arteries,[link widoczny dla zalogowanych], coronary arteries, unlike the use of synthetic graft materials as large-caliber arterial grafts have a higher success rate. Currently, their is still the main vein graft. However, due to vascular disease, amputation, or blood vessels have been collected previously, many patients had no suitable vessels available, the emergence of vascular tissue engineering to address the problem of hope. Key words vascular; tissue engineering; stent in 1912,[link widoczny dla zalogowanych], Garrel in dogs was first reported use of glass and metal tube defects as arterial bypass surgery; of the 20th century and the early '50s Vinyon introduced instead of a synthetic graft artery in the following years, different kinds of materials were used instead of ethylene arteries,[link widoczny dla zalogowanych], the method of large blood vessels in human transplantation with satisfactory results. In small caliber vessels (diameter less than 6mm) transplantation, autologous and synthetic vascular patency rate of vascular obvious differences, 2-year patency rates were 80% and 60%, 5 years the patency rate was 74% and 39% C . In the design of small-caliber vascular three principles must be met: (1) with a high tensile strength and mechanical support of the biological compatibility of components (collagen fibers or other similar elements); (2) the biological compatibility of the elastic component ability to provide retraction and to prevent aneurysm formation; (3) non-activated junction endothelium to prevent thrombosis J. 1 1.1 non-production methods and materials have generally degradable scaffold material for the use of non-degradable stent materials, such as nylon (Nylon), polyester (Dacron) and poly four of the units: 215004, Suzhou University, General Surgery, Second Affiliated Hospital fluoride Expanded (EPTEF) and other J. As non-degradable material does not support endothelial cell adhesion and growth, and the scaffold material can not be degraded, long-term adaptation of blood vessels caused by some disorder; and a similar body of such vessels do not have a normal biological response to vascular wall, such as vascular contraction, easy to form thrombosis; In addition, the anastomotic junction prone to intimal hyperplasia,[link widoczny dla zalogowanych], smooth low sum, in the small-caliber vascular grafts, non-degradable material is gradually phased out, can be considered, the use of non-degradable material for vascular scaffolds is not really on tissue engineering blood vessels. 1.2 to separatist separatist organization for support to complete the natural extracellular matrix (extracellularmatrix, ECM) organization's advantage, with strong mechanical properties and biological compatibility of J, these materials were used as grafts after transplantation, easily re-cells of the host cell. Splitting can be derived from the blood or to blood vessels (small intestine submucosa, smallintestinalsubmucosa, SLS) organization, by the detergent and enzyme inhibitor treatment completion J. It is obvious that the blood vessels to maintain the natural advantages of the structure and composition, and can promote specific sites. After transplantation, it can promote the rapid formation of new blood vessels and infiltration of host cells, then complete the structure of these organizations and remodeling of separatist groups spent in dogs autologous and allogeneic sources of vascular graft patency rate and implicit

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