5α-reductase in molecular biology research _2239 -

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5α-reductase in molecular biology research

Dependents 13 years younger 4 2 (, rCo chemical and pharmacological data suggest that, in non-reproductive clamor within the skin, such as the scalp,[link widoczny dla zalogowanych], 1, 5-a reductase is the major isoenzyme, in androgen target tissues such as prostate, 5n A reductase type 2 is the dominant isoenzyme. using reverse transcription PCR Zhu surgery, pass through the past have been cloned from rat type 2 enzyme cDNA. l and 2 based on 5-a reductase for the differences in substrate affinity and tissue distribution different, some scholars have proposed a type of enzyme in the metabolism of steroid hormones play a role in catabolism, type 2 enzyme from anabolic effect. The following table summarizes the 5a-reductase biochemical and pharmacological properties. M) 11.27.7O. 5 a. 0O. 3KN_ADPH (gM) 29268-134C50, Ftsteride (nM) 12OO50O304K. 230--620-53 enzyme (1 enzyme), PangSC ... / / FertilSter-il. A 1993,59 (1). a 76 to 83 of transdermal estradiol (), the short-term treatment of menopausal symptoms observed have been reported. We report 57 cases of postmenopausal women long-term treatment with estrogen biological and metabolic changes during the observation of other aspects. These women were more than 6 months amenorrhea, a uterus. contraindications, especially hormone therapy, disable more than 3O days of exogenous hormones, were shown to lack estrogen levels, serum E below 93pmoI / L, after determination of the basic indicators of the treatment period (28 day cycle). E: Percutaneous treatment device to help turn every 0.1mg from lower abdomen,[link widoczny dla zalogowanych], hips,[link widoczny dla zalogowanych], buttocks, or every 3.5 days as the Department of rotation to drug to 24.5 days. simple cycle of estrogen (E) of 96 weeks, of which 28 cases with oral medroxyprogesterone acetate (MPA) treatment (E + P group), MPA10mg / day, in the use of E.'s 13 ~ 25 days delivery. all women before treatment and after treatment 24,48,72,96 week serum E:, E., FsH,[link widoczny dla zalogowanych], LH, lipoprotein, total cholesterol, triglycerides, angiotensinogen , renin activity and serum aldosterone. E group l5 women occurs in 20 to 48 weeks of endometrial hyperplasia, or excessive bleeding, plus MPA, then continue medication classified as E + P group was observed. The results show that two groups of women age, no significant difference in body weight during treatment-free growth, no significant differences between the two groups. to filter premenopausal women willing to split the stomach outside the medical birth register 1 Dan Chi 'dependents in 13 Sri Lanka 2 stabbed early and late stages of the bubble measured values for the control, the two groups based on low levels of E and E.. E significantly increased after treatment,[link widoczny dla zalogowanych], both groups at 24 weeks respectively 426pmol / L and 335pmo1 / L. equivalent to the control group of early and late follicular mean value. E increased less, the two groups were 263pmol / L and 244pmol / L. the basis of two gonadotropin levels were significantly higher than young women after treatment decreased (P <O.05), but did not down to the level of the control group and from 24 Zhouhou Wei held at the same level to the end of the experiment. two groups of total cholesterol decreased from 24 weeks onwards, 48 and 96 weeks was significantly decreased, low density lipoprotein wait l bile alcohol only in E + P group was statistically significant decline. two disease-density lipoprotein cholesterol, very low density lipoprotein cholesterol and triglycerides were no significant changes. postmenopausal women based on plasma levels of renin, angiotensinogen, renin activity and serum aldosterone in the normal range of premenopausal women, the application of E:, the two groups did not change significantly. and blood pressure observed during 72 weeks in the normal range of systolic and diastolic blood pressure to drop significantly. E0 given by the skin .1 mg progestin therapy, whether or not combined, in the 24 weeks of blood E. significantly higher levels, gonadotropin levels decline, while total cholesterol, low density lipoprotein cholesterol, systolic and diastolic blood pressure also declined, indicating that percutaneous administration, effective and proven alternative therapies for women to retain the uterus, especially with the long-term application of the joint MPA is safe (the wind pick CHEN Yun Xian Li Jinyuan school) 705

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