Alprostadil methylcobalamin on diabetic peripheral -

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Alprostadil methylcobalamin on diabetic peripheral neuropathy

1. Table 1 The general situation of two groups of patients (± s) delete n sister (mmol / L treatment group 30171354 ± 382 ± 1423.6 ± 2.68.7 ± 10 in control group 27141354 ± 281 ± 1422.5 ± 2.78. 5 ± 12 Note: the control group, P> O.05. 1.2 Methods diabetic diet, insulin (INs) and other comprehensive treatment, disable other anticoagulant, vasodilator, nutrition, nerve agents. the treatment group with saline 250ml, Alprostadil 160mg [Zhunzi H22025800] intravenous drip,[link widoczny dla zalogowanych], every Et1, once every 4 weeks,[link widoczny dla zalogowanych], while application of methylcobalamin 500t ~ g intramuscularly once every Et, 4 weeks. the control group: Methycobal 500t ~ g intramuscular injection, once every Et, 4 weeks. recorded before and after treatment of the symptoms: neurological symptom score, motor signs score, motor nerve conduction velocity (MCV),[link widoczny dla zalogowanych], sensory nerve conduction velocity (SCV). 1.3 evaluation standard reference Dyck. . score standards. 1.4 statistical data (Yuan ± s) indicated significant difference between the two groups asked the t-test analysis. Table 2, neurological symptoms and signs of the two groups were evaluated (± s) group of neurological symptom score nerve n signs score Note: before treatment, P 0.05), neurological symptoms and signs after treatment scores in Table 2,[link widoczny dla zalogowanych], the change of clinical symptoms before and after treatment in Table 3 Table 3. two changes of clinical symptoms before and after treatment control group,[link widoczny dla zalogowanych], treatment group, symptoms of interactive plastic plastic plastic Xuan invalid without a valid and efficient% No Yes hyperalgesia 921I3862I215 hypersensitivity 62416867819 Note: Compared with control group vscontrol, P <O.05. 2 discussions around neuropathy is a common complication of diabetes, the incidence rate of 5% to 50%, pathogenesis are: ischemic theory, metabolic disorders, immune-mediated mechanism J. PGE. is a widespread biological active substances in the body, treatment of diabetic nerve disease mechanisms: ① to improve hemodynamics, vascular smooth muscle cells by increasing the CAMP content to play its vasodilator effect, reducing peripheral resistance; ② improve hemorheology, PGE can inhibit platelet aggregation, reduce the high response and platelet thrombus factor A (TXA) levels, inhibit platelet activation, promoting the activation of platelet thrombus around the reversal has been to improve the deformability of red blood cells; ③ PGE, can activate enzymes and to promote lipoprotein triglyceride hydrolysis, lowering blood lipids and blood viscosity; @ PGE, can stimulate endothelial cells to produce tissue-type plasminogen substances (t-PA), has a direct thrombolysis. prostaglandin these effects help to improve the human blood circulation system, thus raising the dependent neural microcirculation blood supply to improve the recovery of nerve structure and function _3J. In this study, application of alprostadil and methylcobalamin on diabetic peripheral neuropathy, and with methylcobalamin alone were compared with the clinical treatment, combination therapy on reduction of hyperalgesia and sensory efficient than single methylcobalamin improved significantly.

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