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Lansoprazole for the performance of chronic pharyngitis with gastroesophageal reflux disease observation

Form was reduced. (3) is invalid: no significant changes in symptoms of throat inflammation. 8 weeks is still in the throat symptoms review laryngoscope. 1.3.4 Statistical analysis All data (± s) that the symptom scores using t test to compare whether statistically significant differences between groups,[link widoczny dla zalogowanych], the local effect of group differences by chi square test. 2 Results 2.1 symptom scores were compared no difference in symptom score before treatment (P> 0.05). After 8 weeks the treatment group decreased significantly points,[link widoczny dla zalogowanych], compared with before treatment was significantly (P 0.05). Symptom score after treatment between the two groups was statistically significant (P <0.05). Table 1. Table 1 Comparison of clinical symptoms points (points, i ± s) 2.2 Comparison of the throat Inflammation of the two groups after 8 weeks treatment pharyngitis improvement of symptoms, according to local therapeutic efficacy, the treatment group was significantly higher (P < ; 0.05), Table 2. Table 2 Efficacy of throat inflammation (cases) group together, there were markedly effective void efficiency (%) 3 to discuss the role of many factors GERD gastrointestinal motility disorder caused by disease, in addition to the esophagus with esophageal injury and symptoms, but also cause respiratory tract, throat, ear, nose and mouth and other tissues and organs other than esophageal injury. Because the stomach, duodenum arising from gastrointestinal reflux outside the corresponding symptoms, said the performance of esophageal GERD: including non-cardiac chest pain (NCCP), chronic rhinitis, burning mouth, tongue, palate allergies, laryngitis, asthma, chronic cough, throat swallowed foreign body sensation and sleep apnea syndrome, and symptoms of chronic pharyngitis, one of the most common symptoms. Pharyngitis in the pathogenesis of GERD may be caused by: (1) 42 * stomach contents (including acid, digestive enzymes, intestinal contents) break through the lower esophageal sphincter and the esophageal sphincter, reflux material caused by direct contact with the pharyngeal mucosa tissue damage. (2) the lack of protection of pharyngeal mucosal tissues, while mild chronic pharyngitis widespread damage increase makes the reflux material, showing pharyngeal foreign body sensation, cough, sore throat and other symptoms J. Therefore, patients with unknown etiology refractory pharyngitis, should pay attention to history taking, to understand whether the relevant GERD symptoms, patients with suspected GERD should be further examination. For the diagnosis of GERD is the best way to test for PH and 24h esophageal endoscopy, esophageal PH test but the 24h time-consuming to check large pain and lack of basic hospital 24h esophageal PH testing conditions. The exclusion of obvious organic diseases of upper gastrointestinal reflux after the questionnaire, endoscopy, PPI is the primary treatment of experimental treatment of chronic pharyngitis and the most effective way GERD. Gastroesophageal reflux disease in the Montreal definition and classification of states: chronic cough, chronic laryngitis and asthma symptoms and gastric esophageal reflux was significantly associated, chronic cough, chronic pharyngitis, and asthma is a disease caused by multiple factors, gastroesophageal back flow is aggravating factors. In recent years esophageal manifestations of GERD treatment were a large number of studies have shown that lifestyle changes, proton pump inhibitor therapy can improve GERD symptoms, medication regimen 4-8 weeks-4J. Our data show, PPI acid-suppressing effect of the power to quickly improve the typical GERD symptoms, prokinetic drugs can be reduced mosapride acid reflux, inflammatory marzulene can inhibit a variety of substances, gastric and esophageal mucosa for life. Three-drug combination of symptoms of GERD symptoms and significant effect of chronic pharyngitis, and the significant difference between the control group, while the long-term effect needs further observation.
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