MAC Cosmetics UK Theophylline serum concentration -

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Theophylline serum concentration monitoring and rational use of drugs discussed

Drug regimens aminophylline 250mg, intravenous infusion, 2 times a day. The steady-state peak and trough concentrations in Table 1 after the administration of the program adopted. Nearly 96 patients to reach the steady-state peak concentration of the concentration of t and most effective treatment of patients with trough concentrations reach steady-state concentration range of effective treatment. Table 124 steady-state serum theophylline concentrations in patients with back (vg / mD * dosing intravenous aminophylline 25omg - ** Ru per El2 received effective treatment of alkali concentration of 7 ~ 20/Jg/m [Author: Ann Cook, Hefei Pro Lai Provincial Hospital Pharmacy Room (230001 Zhang Shantang. Qu Jian) - Jay respiratory 【parade music. Xu Dewey salamander Cui Fang) Anhui Medical】 7, 1996 Volume 3, Third, a combination of factors such as age and disease, the metabolism of theophylline infectious diseases of young and elderly patients with pulmonary heart disease cOPD theophylline elimination rate results in Table 2 can be seen from Table 2, young patients with infectious diseases the elimination of theophylline was significantly faster than the old land rate of COPD with theophylline in patients with pulmonary heart disease elimination. Zhong 2,[link widoczny dla zalogowanych], two groups comparison of theophylline elimination rate four, CPFX on theophylline serum concentration of 6 patients with the combined use of CPFX and aminophylline theophylline nitrogen than when used alone, the serum theophylline concentration in the corresponding There were significant time differences, the results shown in Table 3. Zhong 3 combined with CPFX on the plasma concentration of theophylline (n = 6) not the same asked the theophylline plasma concentration (, ug/m1) 026 (h) to discuss the efficacy and toxicity of theophylline serum concentration is closely related to in 5 ~ 2O/ml blood concentration range of projects, the bronchodilation and blood drug concentration is proportional to the logarithm. Serum concentrations may occur when more than 20gg/ml sustained toxicity. 7 down this poisoning in 6 cases of serum theophylline concentrations exceed 22 ~ g/m1, including a fall of serum theophylline concentration of arrhythmia was 49.2pg/ml. Theophylline toxicity is not entirely there in order from light to heavy, and some patients before severe toxicity, often without noticeable performance of mild poisoning. Zwiliich other snapped reported 8 cases of theophylline poisoning due to epilepsy patients, the average serum concentration of 54 ~ g / m], of which 3 cases there were no clear in the seizure of other mild symptoms of poisoning. That clinical signs of 33 patients could not accurately reflect the levels of theophylline, only through the blood concentration monitoring to ensure the safety of clinical medicine. Sessler theophylline poisoning in 116 patients with analysis showed that: 88% for the long-term oral theophylline poisoning I aminophylline poisoning from the chronic accumulation of long-term oral aminophylline therefore maintenance therapy in patients with serum theophylline should be regularly concentration monitoring guillotine. Theophylline mainly by the liver, where the liver microsomal enzyme system may affect the drug effect on theophylline metabolism, such as the quinolone antibacterial drugs, propafenone, etc. can cause increased blood concentration of theophylline, and Bobby theophylline drugs properly can significantly reduce the serum concentration]. Various pathophysiological factors such as age, illnesses and diet such as, smoking status, medication time, and so on theophylline metabolism significantly. Because of these reasons that individual differences in metabolism of theophylline large, the same majority of clinical efficacy of treatment is inconsistent, and different dosing regimens will result in theophylline serum concentration and therapeutic effect of the significant differences. Chen Jinzhen such reports, the use of aminophylline 0.2g, orally, 3 times daily program of steady-state blood concentration of 82.6 cases up to the effective therapeutic concentration, while the use of aminophylline 0.1g, orally, 3 times a day program, only 2O cases effective treatment of steady-state plasma concentration range. Ren Yun and other intravenous aminophylline on the two methods were compared and found that the amount used to maintain load increases, the majority of asthma patients with dyspnea were relieved quickly, the higher plasma concentration of theophylline; and the constant load-free infusion solution,[link widoczny dla zalogowanych], only a small number of patients to improve breathing difficulties, blood concentration is generally lower than the former. Thus, clinical application of theophylline preparations must be considered in patients with physiological and pathological status, and combined drug use, select the appropriate dose and dosing interval, and blood concentration monitoring should be effectively applied to clinical resistance theophylline concentration is an objective basis for the adjustment of dosage regimen, the implementation of individualized dosing. In summary, the blood concentration of theophylline dosage regimen design objective indicators; according to the results of therapeutic drug monitoring to adjust dosing regimens, the implementation of individual administration of theophylline poisoning prevention, to ensure treatment, rational use of theophylline preparations effective means. Finally,[link widoczny dla zalogowanych], it is worth mentioning that although the UV spectrophotometric determination of plasma concentrations of theophylline common method, but its poor specificity, and some drugs can cause interference on the determination,[link widoczny dla zalogowanych], attention should be paid. Conditional units can choose high performance liquid chromatography, fluorescence (continued on page 64)
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